Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.

Retrovirus-mediated gene transfer of the human beta-globin gene into hematopoietic stem cells is an attractive approach to the therapy of human beta-globin gene disorders. However, expression of the transduced beta-globin gene linked to its proximal cis-acting sequences (-0.8 to +0.3 kb from the cap...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Leboulch, P, Huang, G M, Humphries, R K, Oh, Y H, Eaves, C J, Tuan, D Y, London, I M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395197/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8039501/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06605.x
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