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Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.

Retrovirus-mediated gene transfer of the human beta-globin gene into hematopoietic stem cells is an attractive approach to the therapy of human beta-globin gene disorders. However, expression of the transduced beta-globin gene linked to its proximal cis-acting sequences (-0.8 to +0.3 kb from the cap...

詳細記述

保存先:
書誌詳細
主要な著者: Leboulch, P, Huang, G M, Humphries, R K, Oh, Y H, Eaves, C J, Tuan, D Y, London, I M
フォーマット: Artigo
言語:Inglês
出版事項: 1994
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC395197/
https://ncbi.nlm.nih.gov/pubmed/8039501
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