Frequent Homologous Recombination Events in Mycobacterium tuberculosis PE/PPE Multigene Families: Potential Role in Antigenic Variability

The PE and PPE (PE/PPE) multigene families of Mycobacterium tuberculosis are particularly GC-rich and share extensive homologous repetitive sequences. We hypothesized that they may undergo homologous recombination events, a mechanism rarely described in the natural evolution of mycobacteria. To test...

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Detalhes bibliográficos
Main Authors: Karboul, Anis, Mazza, Alberto, Gey van Pittius, Nicolaas C., Ho, John L., Brousseau, Roland, Mardassi, Helmi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Population Genetics and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583619/
https://ncbi.nlm.nih.gov/pubmed/18820012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00827-08
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