Targeted Mutagenesis in Pathogenic Leptospira Species: Disruption of the LigB Gene Does Not Affect Virulence in Animal Models of Leptospirosis

The pathogenic mechanisms of Leptospira interrogans, the causal agent of leptospirosis, remain largely unknown. This is mainly due to the lack of tools for genetically manipulating pathogenic Leptospira species. Thus, homologous recombination between introduced DNA and the corresponding chromosomal...

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Dettagli Bibliografici
Autori principali: Croda, Julio, Figueira, Claudio Pereira, Wunder, Elsio A., Santos, Cleiton S., Reis, Mitermayer G., Ko, Albert I., Picardeau, Mathieu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583567/
https://ncbi.nlm.nih.gov/pubmed/18809657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00989-08
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