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Control of Gene Expression in Leptospira spp. by Transcription Activator-Like Effectors Demonstrates a Potential Role for LigA and LigB in Leptospira interrogans Virulence

Leptospirosis is a zoonotic disease that affects ∼1 million people annually, with a mortality rate of >10%. Currently, there is an absence of effective genetic manipulation tools for targeted mutagenesis in pathogenic leptospires. Transcription activator-like effectors (TALEs) are a recently desc...

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Bibliografske podrobnosti
izdano v:Appl Environ Microbiol
Main Authors: Pappas, Christopher J., Picardeau, Mathieu
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616954/
https://ncbi.nlm.nih.gov/pubmed/26341206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02202-15
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