Targeted Mutagenesis in Pathogenic Leptospira Species: Disruption of the LigB Gene Does Not Affect Virulence in Animal Models of Leptospirosis

The pathogenic mechanisms of Leptospira interrogans, the causal agent of leptospirosis, remain largely unknown. This is mainly due to the lack of tools for genetically manipulating pathogenic Leptospira species. Thus, homologous recombination between introduced DNA and the corresponding chromosomal...

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Detalhes bibliográficos
Main Authors: Croda, Julio, Figueira, Claudio Pereira, Wunder, Elsio A., Santos, Cleiton S., Reis, Mitermayer G., Ko, Albert I., Picardeau, Mathieu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583567/
https://ncbi.nlm.nih.gov/pubmed/18809657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00989-08
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