Targeted Mutagenesis in Pathogenic Leptospira Species: Disruption of the LigB Gene Does Not Affect Virulence in Animal Models of Leptospirosis

The pathogenic mechanisms of Leptospira interrogans, the causal agent of leptospirosis, remain largely unknown. This is mainly due to the lack of tools for genetically manipulating pathogenic Leptospira species. Thus, homologous recombination between introduced DNA and the corresponding chromosomal...

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Bibliografiske detaljer
Main Authors: Croda, Julio, Figueira, Claudio Pereira, Wunder, Elsio A., Santos, Cleiton S., Reis, Mitermayer G., Ko, Albert I., Picardeau, Mathieu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583567/
https://ncbi.nlm.nih.gov/pubmed/18809657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00989-08
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