Role of the N-Terminal Amino Acid of Bacillus anthracis Lethal Factor in Lethal Toxin Cytotoxicity and Its Effect on the Lethal Toxin Neutralization Assay

The cytotoxic activity of lethal factor (LF), a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation. These r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Verma, Anita, Wagner, Leslie, Stibitz, Scott, Nguyen, Nga, Guerengomba, Flor, Burns, Drusilla L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2008
Gaiak:
Microbial Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583523/
https://ncbi.nlm.nih.gov/pubmed/18815235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00081-08
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