Role of the N-Terminal Amino Acid of Bacillus anthracis Lethal Factor in Lethal Toxin Cytotoxicity and Its Effect on the Lethal Toxin Neutralization Assay

The cytotoxic activity of lethal factor (LF), a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation. These r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Verma, Anita, Wagner, Leslie, Stibitz, Scott, Nguyen, Nga, Guerengomba, Flor, Burns, Drusilla L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2008
Pynciau:
Microbial Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583523/
https://ncbi.nlm.nih.gov/pubmed/18815235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00081-08
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg