Role of the N-Terminal Amino Acid of Bacillus anthracis Lethal Factor in Lethal Toxin Cytotoxicity and Its Effect on the Lethal Toxin Neutralization Assay

The cytotoxic activity of lethal factor (LF), a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation. These r...

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Bibliographic Details
Main Authors: Verma, Anita, Wagner, Leslie, Stibitz, Scott, Nguyen, Nga, Guerengomba, Flor, Burns, Drusilla L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Microbial Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583523/
https://ncbi.nlm.nih.gov/pubmed/18815235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00081-08
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