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Lipid Binding Region (2303–2332) Is Involved in Aggregation of Recombinant Human FVIII (rFVIII)
Factor VIII (FVIII) is a multi-domain protein that is important in the clotting cascade. Its deficiency causes Hemophilia A, a bleeding disorder. The unfolding of protein domains can lead to physical instability such as aggregation, and hinder their use in replacement therapy. It has been shown that...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583467/ https://ncbi.nlm.nih.gov/pubmed/15858858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.20340 |
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