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Erythrocytic Adenosine Monophosphate as an Alternative Purine Source in Plasmodium falciparum
Plasmodium falciparum is a purine auxotroph, salvaging purines from erythrocytes for synthesis of RNA and DNA. Hypoxanthine is the key precursor for purine metabolism in Plasmodium. Inhibition of hypoxanthine-forming reactions in both erythrocytes and parasites is lethal to cultured P. falciparum. W...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583302/ https://ncbi.nlm.nih.gov/pubmed/18799466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804497200 |
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