Erythrocytic Adenosine Monophosphate as an Alternative Purine Source in Plasmodium falciparum

Plasmodium falciparum is a purine auxotroph, salvaging purines from erythrocytes for synthesis of RNA and DNA. Hypoxanthine is the key precursor for purine metabolism in Plasmodium. Inhibition of hypoxanthine-forming reactions in both erythrocytes and parasites is lethal to cultured P. falciparum. W...

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Bibliographische Detailangaben
Hauptverfasser: Cassera, María B., Hazleton, Keith Z., Riegelhaupt, Paul M., Merino, Emilio F., Luo, Minkui, Akabas, Myles H., Schramm, Vern L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Metabolism and Bioenergetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583302/
https://ncbi.nlm.nih.gov/pubmed/18799466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804497200
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