Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

Cardiolipin is a mitochondria-specific phospholipid known to be intimately involved with apoptosis. However, the lack of appropriate cellular models to date restricted analysis of its role in cell death. The maturation of cardiolipin requires the transacylase tafazzin, which is mutated in the human...

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Autors principals: Gonzalvez, Francois, Schug, Zachary T., Houtkooper, Riekelt H., MacKenzie, Elaine D., Brooks, David G., Wanders, Ronald J.A., Petit, Patrice X., Vaz, Frédéric M., Gottlieb, Eyal
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582890/
https://ncbi.nlm.nih.gov/pubmed/19001123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200803129
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