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The N-clasp of human DNA polymerase κ promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions

DNA bypass polymerases are utilized to transit bulky DNA lesions during replication, but the process frequently causes mutations. The structural origins of mutagenic versus high fidelity replication in lesion bypass is therefore of fundamental interest. As model systems, we investigated the molecula...

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書誌詳細
主要な著者: Jia, Lei, Geacintov, Nicholas E., Broyde, Suse
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582633/
https://ncbi.nlm.nih.gov/pubmed/18931375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn719
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