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Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

In vitro, cytochrome b(5) modulates the rate of cytochrome P450-dependent mono-oxygenation reactions. However, the role of this enzyme in determining drug pharmacokinetics in vivo and the consequential effects on drug absorption distribution, metabolism, excretion, and toxicity are unclear. In order...

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書誌詳細
主要な著者: Finn, Robert D., McLaughlin, Lesley A., Ronseaux, Sebastien, Rosewell, Ian, Houston, J. Brian, Henderson, Colin J., Wolf, C. Roland
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581580/
https://ncbi.nlm.nih.gov/pubmed/18805792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803496200
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