Loading...

Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

In vitro, cytochrome b(5) modulates the rate of cytochrome P450-dependent mono-oxygenation reactions. However, the role of this enzyme in determining drug pharmacokinetics in vivo and the consequential effects on drug absorption distribution, metabolism, excretion, and toxicity are unclear. In order...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Finn, Robert D., McLaughlin, Lesley A., Ronseaux, Sebastien, Rosewell, Ian, Houston, J. Brian, Henderson, Colin J., Wolf, C. Roland
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581580/
https://ncbi.nlm.nih.gov/pubmed/18805792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803496200
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!