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Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

In vitro, cytochrome b(5) modulates the rate of cytochrome P450-dependent mono-oxygenation reactions. However, the role of this enzyme in determining drug pharmacokinetics in vivo and the consequential effects on drug absorption distribution, metabolism, excretion, and toxicity are unclear. In order...

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Detalhes bibliográficos
Main Authors: Finn, Robert D., McLaughlin, Lesley A., Ronseaux, Sebastien, Rosewell, Ian, Houston, J. Brian, Henderson, Colin J., Wolf, C. Roland
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581580/
https://ncbi.nlm.nih.gov/pubmed/18805792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803496200
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