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A role for cytochrome b(5) in the in vivo disposition of anti-cancer and cytochrome P450 probe drugs in mice
The role of microsomal cytochrome b(5) (Cyb5) in defining the rate of drug metabolism and disposition has been intensely debated for several decades. Recently we described mouse models involving the hepatic or global deletion of Cyb5, demonstrating its central role in in vivo drug disposition. We ha...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3935460/ https://ncbi.nlm.nih.gov/pubmed/24115751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.055277 |
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