Prointerleukin-18 Is Activated by Meprin β in Vitro and in Vivo in Intestinal Inflammation

Interleukin-18 (IL-18), a pro-inflammatory cytokine, is a key factor in inflammatory bowel disease (IBD). Caspase-1 activates this cytokine, but other proteases are likely involved in maturation. Because meprin metalloproteinases have been implicated in IBD, the interaction of these proteases with p...

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Bibliographic Details
Main Authors: Banerjee, Sanjita, Bond, Judith S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581578/
https://ncbi.nlm.nih.gov/pubmed/18786924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802814200
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