Cue1p Is an Activator of Ubc7p E2 Activity in Vitro and in Vivo

Ubc7p is a ubiquitin-conjugating enzyme (E2) that functions with endoplasmic reticulum (ER)-resident ubiquitin ligases (E3s) to promote endoplasmic reticulum-associated degradation (ERAD). Ubc7p only functions in ERAD if bound to the ER surface by Cue1p, a membrane-anchored ER protein. The role of C...

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Bibliographic Details
Main Authors: Bazirgan, Omar A., Hampton, Randolph Y.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442330/
https://ncbi.nlm.nih.gov/pubmed/18321851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801122200
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