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Prointerleukin-18 Is Activated by Meprin β in Vitro and in Vivo in Intestinal Inflammation
Interleukin-18 (IL-18), a pro-inflammatory cytokine, is a key factor in inflammatory bowel disease (IBD). Caspase-1 activates this cytokine, but other proteases are likely involved in maturation. Because meprin metalloproteinases have been implicated in IBD, the interaction of these proteases with p...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581578/ https://ncbi.nlm.nih.gov/pubmed/18786924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802814200 |
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