Polycystin-2 Expression Is Regulated by a PC2-binding Domain in the Intracellular Portion of Fibrocystin

Autosomal dominant (ADPKD) and autosomal recessive (ARPKD) polycystic kidney disease are caused by mutations in Pkd1/Pkd2 and Pkhd1, which encode polycystins (PCs) and fibrocystin/polyductin (FPC). Our recent study reported that a deficiency in FPC increases the severity of cystic disease in Pkd2 mu...

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Hlavní autoři: Kim, Ingyu, Li, Cunxi, Liang, Dan, Chen, Xing-Zhen, Coffy, Robert J., Ma, Jie, Zhao, Ping, Wu, Guanqing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581563/
https://ncbi.nlm.nih.gov/pubmed/18782757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805452200
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