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The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus
Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric ion channel complex. However, a functional understanding of the putati...
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| Vydáno v: | eLife |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
eLife Sciences Publications, Ltd
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7728438/ https://ncbi.nlm.nih.gov/pubmed/33164752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60684 |
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