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Do Enthalpy and Entropy Distinguish First in Class From Best in Class?
A drug molecule should bind to its target with high affinity and selectivity. Since the binding affinity is a combined function of the binding enthalpy and the binding entropy, extremely high affinity requires that both terms contribute favorably to binding. The binding enthalpy, however, is notorio...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581116/ https://ncbi.nlm.nih.gov/pubmed/18703160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis2008.07.005 |
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