Interferon-γ and interleukin-4 reciprocally regulate CD8 expression in CD8(+) T cells

The CD8 co-receptor can modulate CD8(+) T cell function through its contributions to T cell receptor (TCR) binding and signaling. Here we show that IFN-γ and IL-4 exert opposing effects on the expression of CD8α mRNA and surface CD8 protein during CD8(+) T cell activation. IL-4 caused down-regulatio...

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Hlavní autoři: Apte, Simon H., Baz, Adriana, Groves, Penny, Kelso, Anne, Kienzle, Norbert
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580749/
https://ncbi.nlm.nih.gov/pubmed/18988742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809549105
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