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Role of Lysine(187) Within the Second Extracellular Loop of the Type A Cholecystokinin Receptor in Agonist-Induced Activation. Use of Complementary Charge-Reversal Mutagenesis to Define a Functionally-Important Interdomain Interaction
Activation of guanine nucleotide-binding protein (G protein)-coupled receptors is believed to involve conformational change that exposes a domain for G protein coupling at the cytosolic surface of the helical confluence, although the mechanisms for achieving this are not well understood. This confor...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580722/ https://ncbi.nlm.nih.gov/pubmed/17381074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0622468 |
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