Immunity Related GTPase Irgm1 promotes expansion of activated CD4(+) T cell populations by preventing interferon-γ-induced cell death

Mice deficient in interferon-γ (IFN-γ) inducible immunity-related GTPase, Irgm1, display defective host resistance to a variety of intracellular pathogens. This increased susceptibility to infection is associated with impaired IFN-γ-dependent macrophage microbicidal activity in vitro. Here, we show...

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Autors principals: Feng, Carl G., Zheng, Lixin, Jankovic, Dragana, Báfica, André, Cannons, Jennifer L., Watford, Wendy T., Chaussabel, Damien, Hieny, Sara, Caspar, Patricia, Schwartzberg, Pamela L., Lenardo, Michael J., Sher, Alan
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580721/
https://ncbi.nlm.nih.gov/pubmed/18806793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1653
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