Calcium Sensitive Adenylyl Cyclases in Depression and Anxiety: Behavioral and Biochemical Consequences of Isoform Targeting

BACKGROUND: Adenylyl cyclases (ACs) represent a diverse family of enzymes responsible for the generation of cAMP, a key intracellular second messenger. Ca(2+)/calmodulin-stimulated AC1 and AC8 isoforms, as well as the calcium-inhibited AC5 isoform, are abundantly expressed within limbic regions of t...

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Main Authors: Krishnan, Vaishnav, Graham, Ami, Mazei-Robison, Michelle S., Lagace, Diane C., Kim, Kyoung-Shim, Birnbaum, Shari, Eisch, Amelia J., Han, Pyung-Lim, Storm, Daniel R., Zachariou, Venetia, Nestler, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580057/
https://ncbi.nlm.nih.gov/pubmed/18468583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.03.026
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