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Distinct Roles of Adenylyl Cyclases 1 and 8 in Opiate Dependence: Behavioral, Electrophysiological, and Molecular Studies

BACKGROUND: Opiate dependence is a result of adaptive changes in signal transduction networks in several brain regions. Noradrenergic neurons of the locus coeruleus (LC) have provided a useful model system in which to understand the molecular basis of these adaptive changes. One of most robust signa...

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Detalhes bibliográficos
Main Authors: Zachariou, Venetia, Liu, Rongjian, Laplant, Quincey, Xiao, Guanghua, Renthal, William, Chan, Guy C., Storm, Daniel R., Aghajanian, George, Nestler, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442273/
https://ncbi.nlm.nih.gov/pubmed/18222416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2007.11.021
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