Type 8 Adenylyl Cyclase Is Targeted to Excitatory Synapses and Required for Mossy Fiber Long-Term Potentiation

Mossy fiber/CA3 long-term potentiation (LTP) is hypothesized to depend on cAMP signals generated by Ca(2+)-stimulated adenylyl cyclases AC1 or AC8. AC1 gene knock-out mice (AC1(–)(/)(–)) show a partial reduction in mossy fiber LTP, suggesting that either AC8 activity is also critical for mossy fiber...

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Publicat a:J Neurosci
Autors principals: Wang, Hongbing, Pineda, Victor V., Chan, Guy C. K., Wong, Scott T., Muglia, Louis J., Storm, Daniel R.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2003
Matèries:
Cellular/Molecular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740883/
https://ncbi.nlm.nih.gov/pubmed/14585998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-30-09710.2003
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