Smad4 haploinsufficiency: a matter of dosage

BACKGROUND: The inactivation of tumor suppressor genes follows Alfred Knudson's 'two-hit' model: both alleles need to be inactivated by independent mutation events to trigger tumor formation. However, in a minority of tumor suppressor genes a single hit is sufficient to initiate tumor...

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Detalhes bibliográficos
Main Authors: Alberici, Paola, Gaspar, Claudia, Franken, Patrick, Gorski, Marcin M, de Vries, Ingrid, Scott, Rodney J, Ristimäki, Ari, Aaltonen, Lauri A, Fodde, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580039/
https://ncbi.nlm.nih.gov/pubmed/19014666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8417-1-2
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