SMAD4 Haploinsufficiency Associates with Augmented Colonic Inflammation in Select Humans and Mice

SMAD4 is a common mediator of the TGF-beta signaling pathway. One of the members of this pathway, TGF-beta 1, has an important role in controlling gut inflammation in relation to the continuous stimulation of the intestinal microbiota. SMAD4 haploinsufficiency in humans has been linked to juvenile p...

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Главные авторы: Szigeti, Reka, Pangas, Stephanie A., Nagy-Szakal, Dorottya, Dowd, Scot E., Shulman, Robert J., Olive, Anthony P., Popek, Edwina J., Finegold, Milton J., Kellermayer, Richard
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875295/
https://ncbi.nlm.nih.gov/pubmed/23090737
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