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Pharmaco-Informatics: Accelerated NPEM Population Pharmacokinetic Modeling, “Maximum Entropy” (ME) Parameter Distributions, and New “Multiple Model” (MM) Stochastic Dosage Regimens now by Oral, IM, and both Intermittent and Continous IV
New techniques have greatly increased the speed of NPEM population analysis 20 to 30-fold. Development of ME parameter distributions now permits use of literature population parameter values to create discrete probability density functions (PDF's) for MM dosage design. The MM regimens are no lo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579852/ |
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