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Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis
AML1-ETO is generated from t(8;21)(q22;q22), which is a common form of chromosomal translocation associated with development of acute myeloid leukemia (AML). Although full-length AML1-ETO alone fails to promote leukemia because of its detrimental effects on cell proliferation, an alternatively splic...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579385/ https://ncbi.nlm.nih.gov/pubmed/18952841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802696105 |
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