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HCO(3)(−)/Cl(−) anion exchanger SLC4A2 is required for proper osteoclast differentiation and function
As the only cell capable of bone resorption, the osteoclast is a central mediator of skeletal homeostasis and disease. To efficiently degrade mineralized tissue, these multinucleated giant cells secrete acid into a resorption lacuna formed between their apical membrane and the bone surface. For each...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579356/ https://ncbi.nlm.nih.gov/pubmed/18971331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808763105 |
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