SLC4A2-mediated Cl(−)/HCO(3)(−) exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts

Bone remodeling requires osteoclasts to generate and maintain an acidified resorption compartment between the apical membrane and the bone surface to solubilize hydroxyapatite crystals within the bone matrix. This acidification process requires (i) apical proton secretion by a vacuolar H(+)-ATPase,...

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Bibliographic Details
Main Authors: Coury, Fabienne, Zenger, Serhan, Stewart, Andrew K., Stephens, Sebastien, Neff, Lynn, Tsang, Kelly, Shull, Gary E., Alper, Seth L., Baron, Roland, Aliprantis, Antonios O.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568349/
https://ncbi.nlm.nih.gov/pubmed/23341620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206392110
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