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Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapy
Unlike most DNA viruses, poxviruses replicate in the cytoplasm of host cells. They encode enzymes needed for genome replication and transcription, including their own thymidine and thymidylate kinases. Some herpes viruses encode only 1 enzyme catalyzing both reactions, a peculiarity used for prodrug...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579350/ https://ncbi.nlm.nih.gov/pubmed/18971333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804525105 |
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