Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapy

Unlike most DNA viruses, poxviruses replicate in the cytoplasm of host cells. They encode enzymes needed for genome replication and transcription, including their own thymidine and thymidylate kinases. Some herpes viruses encode only 1 enzyme catalyzing both reactions, a peculiarity used for prodrug...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Caillat, Christophe, Topalis, Dimitri, Agrofoglio, Luigi A., Pochet, Sylvie, Balzarini, Jan, Deville-Bonne, Dominique, Meyer, Philippe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579350/
https://ncbi.nlm.nih.gov/pubmed/18971333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804525105
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