Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

The ROCK-I serine/threonine protein kinase mediates the effects of RhoA to promote the formation of actin stress fibres and integrin-based focal adhesions. ROCK-I phosphorylates the unconventional G-protein RhoE on multiple N- and C-terminal sites. These phosphorylation events stabilise RhoE, which...

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Main Authors: Komander, David, Garg, Ritu, Wan, Paul T C, Ridley, Anne J, Barford, David
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579254/
https://ncbi.nlm.nih.gov/pubmed/18946488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.226
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