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Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
The ROCK-I serine/threonine protein kinase mediates the effects of RhoA to promote the formation of actin stress fibres and integrin-based focal adhesions. ROCK-I phosphorylates the unconventional G-protein RhoE on multiple N- and C-terminal sites. These phosphorylation events stabilise RhoE, which...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579254/ https://ncbi.nlm.nih.gov/pubmed/18946488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.226 |
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