Cytokines and LPS induce iNOS but not Enzyme Activity in Adult Rat Cardiomyocytes

There is evidence that nitric oxide (NO) formation in adult cardiomyocytes stimulated with lipopolysaccharide (LPS) does not commensurate with iNOS levels. Tetrahydrobiopterin (BH(4)) is a key factor in the stabilization and NO production by iNOS homodimer. Thus we hypothesized that BH(4) is a limit...

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Detalhes bibliográficos
Main Authors: Vásquez-Vivar, Jeannette, Whitsett, Jennifer, Ionova, Irina, Konorev, Eugene, Zielonka, Jacek, Kalyanaraman, Balaraman, Shi, Yang, Pieper, Galen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2578873/
https://ncbi.nlm.nih.gov/pubmed/18634867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.06.017
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