Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants

Production of aberrant messenger ribonucleoprotein particles (mRNPs) is subject to quality control (QC). In yeast strains carrying mutations of the THO complex, transcription induction triggers a number of interconnected QC phenotypes: (1) rapid degradation of several mRNAs; (2) retention of a fract...

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Detalhes bibliográficos
Main Authors: Assenholt, Jannie, Mouaikel, John, Andersen, Kasper R., Brodersen, Ditlev E., Libri, Domenico, Jensen, Torben Heick
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2578857/
https://ncbi.nlm.nih.gov/pubmed/18824516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1108008
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