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Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants

The nuclear exosome is involved in numerous RNA metabolic processes. Exosome degradation of rRNA, snoRNA, snRNA and tRNA in Saccharomyces cerevisiae is activated by TRAMP complexes, containing either the Trf4p or Trf5p poly(A) polymerase. These enzymes are presumed to facilitate exosome access by ap...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rougemaille, Mathieu, Gudipati, Rajani Kanth, Olesen, Jens Raabjerg, Thomsen, Rune, Seraphin, Bertrand, Libri, Domenico, Jensen, Torben Heick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864968/
https://ncbi.nlm.nih.gov/pubmed/17410208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601669
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