Adult-Like Anti-Mycobacterial T Cell and In Vivo Dendritic Cell Responses Following Neonatal Immunization with Ag85B-ESAT-6 in the IC31® Adjuvant

BACKGROUND: With the exception of some live vaccines, e.g. BCG, subunit vaccines formulated with “classical” adjuvants do not induce similar responses in neonates as in adults. The usual neonatal profile is characterized by lower levels of TH1-associated biomarkers. This has hampered the development...

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Main Authors: Kamath, Arun T., Rochat, Anne-Françoise, Valenti, Mario P., Agger, Else Marie, Lingnau, Karen, Andersen, Peter, Lambert, Paul-Henri, Siegrist, Claire-Anne
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577009/
https://ncbi.nlm.nih.gov/pubmed/18997860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003683
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