Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose

BACKGROUND: Previously we have shown that Ag85B-TB10.4 is a highly efficient vaccine against tuberculosis when delivered in a Th1 inducing adjuvant based on cationic liposomes. Another Th1 inducing adjuvant, which has shown a very promising profile in both preclinical and clinical trials, is IC31®....

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Hlavní autoři: Aagaard, Claus, Hoang, Truc Thi Kim Thanh, Izzo, Angelo, Billeskov, Rolf, Troudt, JoLynn, Arnett, Kim, Keyser, Andrew, Elvang, Tara, Andersen, Peter, Dietrich, Jes
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691953/
https://ncbi.nlm.nih.gov/pubmed/19529771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005930
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