Post-transcriptional Control of CCAAT/Enhancer-binding Protein β (C/EBPβ) Expression: FORMATION OF A NUCLEAR HuR-C/EBPβ mRNA COMPLEX DETERMINES THE AMOUNT OF MESSAGE REACHING THE CYTOSOL

In 3T3-L1 cells, HuR is constitutively expressed and prior to induction of differentiation localized predominantly to the nucleus. Within minutes of induction of differentiation, nuclear HuR binds to its target ligand mRNAs, and the complexes appear to move to the cytosol. One ligand mRNA is the CCA...

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Bibliografiska uppgifter
Huvudupphovsmän: Cherry, Joy, Jones, Heath, Karschner, Vesna A., Pekala, Phillip H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2008
Ämnen:
RNA: Processing and Catalysis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576548/
https://ncbi.nlm.nih.gov/pubmed/18678862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805659200
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