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Regulation of the epithelial Na(+) channel by endothelin-1 in rat collecting duct

We used patch-clamp electrophysiology to investigate regulation of the epithelial Na(+) channel (ENaC) by endothelin-1 (ET-1) in isolated, split-open rat collecting ducts. ET-1 significantly decreases ENaC open probability by about threefold within 5 min. ET-1 decreases ENaC activity through basolat...

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Detalhes bibliográficos
Main Authors: Bugaj, Vladislav, Pochynyuk, Oleh, Mironova, Elena, Vandewalle, Alain, Medina, Jorge L., Stockand, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576140/
https://ncbi.nlm.nih.gov/pubmed/18667482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90321.2008
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