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Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions

Eukaryotic exonuclease 1 functions in replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class switch recombination, and somatic hypermutation. The enzyme has 5′–3′ exonuclease, flap endonuclease, and weak RNaseH activity in vitro, but it has been difficult t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vallur, Aarthy C., Maizels, Nancy
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575450/
https://ncbi.nlm.nih.gov/pubmed/18940926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805327105
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