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Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions

Eukaryotic exonuclease 1 functions in replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class switch recombination, and somatic hypermutation. The enzyme has 5′–3′ exonuclease, flap endonuclease, and weak RNaseH activity in vitro, but it has been difficult t...

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Hlavní autoři: Vallur, Aarthy C., Maizels, Nancy
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575450/
https://ncbi.nlm.nih.gov/pubmed/18940926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805327105
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