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Patch–clamp coordinated spectroscopy shows P2X(2) receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels

ATP-gated P2X receptors display ion permeability increases within seconds of receptor activation as the channels enter the I(2) state, which is permeable to organic cations and dye molecules. The mechanisms underlying this important behavior are not completely understood. In one model, the I(2) stat...

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Библиографические подробности
Главные авторы: Chaumont, Severine, Khakh, Baljit S.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575328/
https://ncbi.nlm.nih.gov/pubmed/18689682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803008105
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