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Patch–clamp coordinated spectroscopy shows P2X(2) receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels
ATP-gated P2X receptors display ion permeability increases within seconds of receptor activation as the channels enter the I(2) state, which is permeable to organic cations and dye molecules. The mechanisms underlying this important behavior are not completely understood. In one model, the I(2) stat...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575328/ https://ncbi.nlm.nih.gov/pubmed/18689682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803008105 |
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