Synergistic control of T cell development and tumor suppression by diacylglycerol kinase α and ζ

Diacylglycerol (DAG) kinases (DGKs) are a family of enzymes that convert DAG to phosphatidic acid (PA), the physiologic functions of which have been poorly defined. We report here that DGK α and ζ synergistically promote T cell maturation in the thymus. Absence of both DGKα and ζ (DGKα(−/−)ζ(−/−)) r...

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Hauptverfasser: Guo, Rishu, Wan, Chi-Keung, Carpenter, Jeffery H., Mousallem, Talal, Boustany, Rose-Mary N., Kuan, Chien-Tsun, Burks, A. Wesley, Zhong, Xiao-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575297/
https://ncbi.nlm.nih.gov/pubmed/18689679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711856105
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