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Wounding Sheets of Epithelial Cells Activates the Epidermal Growth Factor Receptor through Distinct Short- and Long-Range Mechanisms

Wounding epithelia induces activation of the epidermal growth factor receptor (EGFR), which is absolutely required for induction of motility. ATP is released from cells after wounding; it binds to purinergic receptors on the cell surface, and the EGFR is subsequently activated. Exogenous ATP activat...

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Detalhes bibliográficos
Main Authors: Block, Ethan R., Klarlund, Jes K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575185/
https://ncbi.nlm.nih.gov/pubmed/18799627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-01-0097
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